Argyle come off of a 1:0 victory at the other side of Sheffield. Steve MacLean netted the winner against his former club to spoil Wednesday's unbeaten home record. And Argyle look to do the same come Saturday afternoon, they will be seeking to break United's deadlock of 12 games unbeaten at Bramall Lane (including last season).
Plymouth Gaffer Paul Sturrock said: "This is a vitally important game. I would like to come back with three points - I am getting greedy in my old age. We went there last year and got a result, and there is a confidence about the players.
"There was a real buzz about them on they way home (from Sheffield Wednesday). Bramall Lane is difficult place to go. They haven't lost a game at home this season and they are one of the form teams in the league.
"They have got some good players who can hurt you. We have got to go there and play better than we did the other night.
"They are a top six club in this division. Suspensions, injuries, lady luck, referees can all affect, but I think they will be a top six team."