The Blades played the first of a triple bill of away games last Tuesday night at Walsall and were handed an astonishing blow at the Banks Stadium when despite coming twice from behind still left the Midlands without a single point following a 3-2 defeat. Lee Williamson and Ched Evans were on target for the Blades.
Blades boss Danny Wilson now has a selection headache ahead of this weekend's game; Lescinel Jean-Francois (knee), Kevin McDonald (hamstring), Nick Montgomery (groin) and Chris Morgan (knee) are all absent through injury.
However he is boosted by the return of defenders Matt Lowton, 22 and Harry Maguire, 18 from suspension - the pair were both dismissed during United's recent 3-2 home defeat to Oldham Athletic.
Brentford, also founded in 1889 hosted Exeter City on Tuesday night, winning 2-0 with a brace from Saido Berahino. It was there first win in four matches and placed them ninth in the table; just six points away from the play-offs.
Bees boss Uwe Rosler will be forced to check on the fitness of duo Toumani Diagouraga (knock) and Shaleum Logan (hamstring) after both near close to recovery after suffering different injuries. Meanwhile Kevin O'Connor (foot) remains sidelined whilst former Rotherham United defender Marcus Bean (ankle) remains on the injury list.
Goalkeeper Richard Lee could return after recovering from illness - though he may opt to retain Simon Moore in the number one jersey.
The Bees could field former Sheffield United trialist Shaleum Logan, 23 who played for the Blades in pre-season fixtures against Mansfield Town and Burton Albion in July 2010. He had initially joined from Manchester City but failed to secure a contract. He has also represented Stockport County, Scunthorpe United, Grimsby Town and Tranmere Rovers on loan.