Fellow midfielder Stephen Quinn could return to the squad, but manager Gary Speed will leave the decision up to the Irishman, who missed last Saturday's 1-0 win at Millwall for personal reasons.
Reid, on loan from Sunderland, will start at Bramall Lane for the first time after scoring the winner at the New Den.
Speed, keen to extend Reid's stay with the Blades, has no new injury or suspension worries and will choose his side from the same squad if Quinn misses out again.
The Blades, who secured their first win in five matches at Millwall, have lost three and drawn one of their last four home games in the Championship.
Source: PA
Source: PA