Nosworthy has been ruled out with an ankle injury while Adams could be forced to make several more changes following the 4-2 defeat at Burnley as goalkeeper Richard Wright (thigh), defenders Jean Calve and Matt Lowton and midfielder Leon Britton (all groin) are struggling.
Steve Simonsen, dropped for Adams' first game in charge at Turf Moor, will return in goal if Wright fails to make it.
Midfielder Nick Montgomery and defender Kyle Bartley are available again following suspension and likely to go straight into Adams' starting line-up, while striker Daniel Bogdanovic is pushing for a return.
The Blades have lost their last three league games - they have won one of their last six - and lie two points above the relegation zone.
Source: PA
Source: PA