Both the Blades and the Hammers are battling out for a Play-Off place in the Championship and honours are even as each side beat each other in their own backyards.
However when push came to shove the two clubs could not be separated at Upton Park in the cup as Phil Jagielka's second half header cancelled out Marlon Harewood's first half opener.
The home side welcome back Robert Kozluk who has recently returned from a loan spell at Preston North End and Ashley Ward who has overcome a niggling knee injury.
New signing Tommy Johnson could be called into action as he is yet to be cup tied and should add variation to a some what slim forward line.
Keeper Paddy Kenny and Midfielder Alan Quinn both escaped International duty in midweek against Portugal un-injured as they failed to make a minute each on the pitch.
PREDICTED STARTING LINE-UP:
Paddy Kenny, Leigh Bromby, Phil Jagielka, Chris Morgan, Derek Geary, Andy Liddell, Alan Quinn, Michael Tonge, Jon Harley, Ashley Ward, Andy Gray.
The Hammers welcome back Czech International Thomas Repka who returns from suspension whilst old skool Steve Lomas could return after playing 75 minutes against Charlton Athletic in midweek for the reserves.
The visitors will however be without Christian Dailly and Matthew Etherington are sidelined and Gavin Williams who is cup-tied.
PREDICTED STARTING LINE-UP:
Stephen Bywater, Nigel Reo-Coker, Malky Mackay, Anton Ferdinand, Chris Powell, Hayden Mullins, Carl Fletcher, Teddy Sheringham, Mark Noble, Marlon Harewood, Bobby Zamora.