In their first outing since the dismal displays in Israel in the UEFA European U21s Championships, England's youngsters will be hoping to right a few wrongs going into tonight's clash between the Auld Enemy.
The Three Lions were defeated 0:1, 1:3 and 0:1 to Italy, Norway and hosts Israel respectively in June's tournament, leaving Stuart Pearce's men rock bottom of Group A, boasting not a single point.
Pearce has since been relieved of his duties as U21s boss, with the role being temporarily overtaken by first team manager Roy Hodgson, who will oversee tonight's game as well as tomorrow's senior meeting at Wembley.
Tonight's squad will consist of Blades goalkeeper George Long, who has been given the call-up to the U21 ranks, following his selection for the U20s World Cup two months ago.
Long joined up with his international team-mates at St George's Park after United's 3:1 defeat to Brentford, and will be battling for a stint tonight ahead of fellow shot-stoppers Jack Butland, Jonathan Bond and Sam Johnstone.
England's squad has players with a decent amount of Premier League experience within it. The likes of Liverpool's Raheem Sterling, Everton's Ross Barkley and Sunderland's Connor Wickham are all set to feature.
Tom Ince of Blackpool and Luke Shaw of Southampton, however, have both pulled out due to injuries.
Scotland named Celtic striker Tony Watt in their squad tonight, alongside club team-mates Dylan McGeouch and Stuart Findlay.
Kick-off is at 7:30pm.